Preparation of VYXEOS

Watch a detailed walk-through of the steps to prepare and administer VYXEOS

See below for step-by-step instructions and a downloadable PDF

VYXEOS: Preparation and Administration Instructions

Steps for preparing and administering VYXEOS1

Equilibrate the appropriate number of vials of VYXEOS to room temperature for 30 minutes

1

Reconstitute each vial with 19 mL of Sterile Water for Injection using a sterile syringe

  • Carefully swirl the contents of the vial for 5 minutes while gently inverting the vial every 30 seconds
  • After reconstitution but before final dilution, each mL of VYXEOS will contain 2.2 mg of daunorubicin and 5 mg of cytarabine

Do not heat, vortex, or shake vigorously

2

After reconstitution, let rest for 15 minutes

  • The reconstituted product should be an opaque, purple, homogeneous dispersion, essentially free from visible particulates
3

Gently invert each vial 5 times and aseptically withdraw the calculated volume of reconstituted product from the vial(s) using a sterile syringe

If the reconstituted product is not diluted into an infusion bag immediately, it can be stored at 2°C to 8°C (36°F to 46°F) for up to 4 hours
4

Transfer the calculated volume to an infusion bag containing 500 mL of 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP

  • Discard any unused portion or residual product remaining in the vial and do not save any unused portions for later administration

Gently invert the bag to mix the solution

  • Only solutions without visible particulates should be used
If the diluted product is not used immediately, it can be stored at 2°C to 8°C (36°F to 46°F) for up to 4 hours