What to expect with VYXEOS
VYXEOS (vix-e-ose) is administered as an intravenous (IV) infusion using a central IV line or peripherally inserted central catheter.
VYXEOS is given in 2 phases, known as induction and consolidation. Induction is the first phase of treatment, used to control the disease and reduce the number of leukemia cells (blasts) to achieve remission (a decrease in or disappearance of signs and symptoms of cancer). Consolidation is given to maintain remission and decrease the number of any remaining blasts.
A full VYXEOS treatment course can consist of up to 2 cycles of induction and up to 2 cycles of consolidation. Your doctor will determine what is needed based on your progress.See more information about this dosing schedule.
Why you might need multiple cycles of induction and consolidation
Your VYXEOS dosing schedule is designed specifically for you by your healthcare team based on your progress at certain time points during treatment.
Second consolidation cycles may be administered to ensure the disease remains controlled.
What to tell your healthcare team before treatment with VYXEOS
Known or suspected pregnancy.
VYXEOS can harm your unborn baby and should not be received during pregnancy. Females and males of reproductive age should use effective contraception during treatment and for 6 months following the last dose of VYXEOS. Additionally, you should not breastfeed during treatment with VYXEOS and for at least 2 weeks after the last dose.
History of heart disease.
VYXEOS can cause heart-related side effects. Tell your healthcare team about any history of heart disease, radiation to the chest, or previous chemotherapy.
History of copper-processing disorder.
VYXEOS contains copper and may cause copper overload in patients with Wilson’s disease or other copper-processing disorders.
Additional medications you may be taking.
It is important to tell your healthcare team about all medications you may be taking, including any vitamins or supplements, to determine what you may need to discontinue during treatment. Some medications may affect treatment with VYXEOS.
Previous chemotherapy treatment.
Tell your healthcare team about any prior treatment with an anthracycline such as daunorubicin, doxorubicin, epirubicin, or idarubicin.
What to tell your healthcare team during treatment with VYXEOS
You should immediately contact a member of your healthcare team if you experience any of the following:
Fever, signs of infection, or bruising or bleeding.
VYXEOS can cause a severe decrease in blood cells (white and red blood cells and cells that prevent bleeding, called platelets), which can result in serious infection and/or bleeding and possibly lead to death. Your doctor will monitor your blood counts during treatment with VYXEOS. You should tell your doctor about new onset fever or symptoms of infection or if you notice signs of bruising or bleeding.
Signs of heart failure.
VYXEOS can cause heart-related side effects such as shortness of breath or trouble breathing; swelling or fluid retention, especially in the feet, ankles, or legs; or unusual tiredness.
VYXEOS can damage the skin if it leaks out of the vein. Tell your doctor right away if you experience symptoms of burning, stinging, or blisters and skin sores at the injection site.
Signs of hypersensitivity reactions, including anaphylaxis.
VYXEOS may cause allergic reactions, including anaphylaxis. Seek immediate medical attention if you develop signs and symptoms of anaphylaxis, such as difficulty breathing, severe itching, skin rash or hives, or swelling of the face, lips, mouth, or tongue.
These are not all of the possible side effects of VYXEOS. Be sure to speak to your healthcare team about any side effects you have. You will also have blood tests done to check for side effects during treatment with VYXEOS.